Not with the add-on optimizers (ES and 2ES series) or the first generation of smart module junction boxes (JES series.) In order to optimize energy harvest, an integrated Maximizer junction box must be used on all modules connected to the same inverter. The system is priced low enough to generate an impressive ROI with an integrated Maximizer on every module.
If using TS4-L or TS4-O (either integrated or with TS4-R retrofit), it may be possible depending on your site layout.
Learn more about selective deployment of optimization here.